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Synthesis and Biological Properties of some New Lead Sulphonamide and Carboxamide Scaffolds Bearing Coumarin Moieties (Mini Review)

Author(s):

Cosmas Chinweike Eze*, Mercy Amarachukwu Ezeokonkwo, Benjamin Ebere Ezema, Abraham Efeturi Onoabedje and David Izuchukwu Ugwu   Pages 1 - 18 ( 18 )

Abstract:


Coumarin, sulphonamide and amide scaffolds exhibit diverse pharmacological features and constitute an important class of therapeutic agents. In this review, we have discussed the synthesis, biological properties, and SAR of coumarins containing sulphonamide or amide group in the last seven years. Many reviews on the therapeutic activities of coumarins, sulphonamides, and amides have been published, hence the authors focused on coumarin-linked sulphonamide or amide scaffolds. The review provides information on the synthetic route to new coumarins containing sulphonamide or amide groups with improved pharmacological properties.

Keywords:

Coumarin, Sulphonamide, Amide, Biological properties, Synthesis, SAR.

Affiliation:

Natural Science Unit, School of General studies, University of Nigeria, Nsukka, Enugu State 410001, Department of Pure & Industrial Chemistry, University of Nigeria, Nsukka, Enugu State 410001, Department of Pure & Industrial Chemistry, University of Nigeria, Nsukka, Enugu State 410001, Department of Pure & Industrial Chemistry, University of Nigeria, Nsukka, Enugu State 410001, Department of Pure & Industrial Chemistry, University of Nigeria, Nsukka, Enugu State 410001



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