Olagoke Zacchaeus Olatunde, Jianping Yong* and Canzhong Lu Pages 1 - 28 ( 28 )
Anticancer drugs based on the microtubules target are potent mitotic spindle poison agents, which interacted directly with the microtubules, and were classified as microtubule-stabilizing agents and microtubule-destabilizing agents. Researchers have worked tremendously towards the improvements of anticancer drugs, in terms of improving the efficacy, solubility and reducing the side effects, which brought about advancement in chemotherapy. In this review, we focused on describing the discovery, structures and functions of the microtubules as well as the progress of anticancer agents related to the microtubules, which will provide adequate references for researchers.
Microtubules, Structures, Functions, Mechanism, Target, Anticancer agents
Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Xiamen Institute of Rare-earth Materials, Chinese Academy of Sciences, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences