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Regulation of Catechins in Uric Acid Metabolism Disorder Related Human Diseases

Author(s):

Dan Wu, Wenji Zhang, Xingfei Lai, Qiuhua Li, Lingli Sun, Ruohong Chen, Shili Sun* and Fanrong Cao   Pages 1 - 10 ( 10 )

Abstract:


Background: Uric acid is the end product of purine metabolism in humans. High uric acid levels form sodium urate crystals that trigger biological processes, which lead to the development of several diseases, including diabetes, hyperuricemia, gout, inflammatory disease, kidney disease, cardiovascular disease and hypertension. Catechins have been suggested to be beneficial for the regulation of uric acid metabolic disorders due to their powerful antioxidant and antiinflammatory properties.

Objectives: To identify an effective and safe natural substance that can decrease levels of serum uric acid to improve uric acid metabolism disorders.

Methods: A search was performed on PubMed, Web of Science and Google Scholar to identify comprehensive studies that presented summarize data on the use of catechins in lowering uric acid levels in diseases.

Results: This review details the role of catechins in inhibiting the activity of xanthine oxidase to decrease uric acid overproduction in liver and in regulating expressions of uric acid transporters, URAT1, OAT1, OAT3, ABCG2 and GLUT9, to balance levels of uric acid secretion and reabsorption through the kidney and intestine. Additionally, Catechins were also found to prevent monosodium urate-induced inflammatory reaction. In vivo, catechins can be used to decrease high uric acid levels that result from hyperuricemia and related diseases.

Conclusion: Catechins can be used to maintain the balance of uric acid metabolism.

Keywords:

Catechins, uric acid, inflammation, hyperuricemia, nephropathy, metabolic syndrome.

Affiliation:

College of Horticulture, South China Agricultural University, Guangzhou 510000, Tea Research Institute, Guangdong Academy of Agricultural Sciences/Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation & Utilization, Guangzhou 510640, Tea Research Institute, Guangdong Academy of Agricultural Sciences/Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation & Utilization, Guangzhou 510640, Tea Research Institute, Guangdong Academy of Agricultural Sciences/Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation & Utilization, Guangzhou 510640, Tea Research Institute, Guangdong Academy of Agricultural Sciences/Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation & Utilization, Guangzhou 510640, Tea Research Institute, Guangdong Academy of Agricultural Sciences/Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation & Utilization, Guangzhou 510640, Tea Research Institute, Guangdong Academy of Agricultural Sciences/Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation & Utilization, Guangzhou 510640, College of Horticulture, South China Agricultural University, Guangzhou 510000



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