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Future and Perspectives of the Zika Virus: Drug Repurposing as a Powerful Tool for Treatment Insights

Author(s):

Denise Rampini, Diego Campos Prieto, Ana Luisa Colzi, Renan Vinícius de Araújo and Jeanine Giarolla*   Pages 1 - 12 ( 12 )

Abstract:


The Zika virus (ZIKV) infection is a major public health concern in Brazil and worldwide, being a rapidly spreading disease with possible severe complications for pregnant women and neonates. There is currently no preventative therapy or specific treatment available. Within this context, drug repositioning is a very promising approach for the discovery of new treatment compounds, since old drugs may become new ones. Therefore, this paper aims to perform a literature mini-review to identify promising compounds to combat this virus. The mechanism of action at the molecular level and, when possible, the structure-activity relationship of prototypes are discussed. Among the candidates identified, we highlight sofosbuvir, chloroquine and suramine, which present a higher quantity of experimental data to draw on for our discussion. The current treatment is palliative, therefore, this study is of paramount importance in identifying drug candidates useful for combating ZIKV.

Keywords:

Zika virus, drug repositioning, treatment, medicinal chemistry, infection disease, drug design

Affiliation:

Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Cidade Universitária, 05508-000, São Paulo, Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Cidade Universitária, 05508-000, São Paulo, Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Cidade Universitária, 05508-000, São Paulo, Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Cidade Universitária, 05508-000, São Paulo, Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Cidade Universitária, 05508-000, São Paulo



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