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Herbal Extracts with Antifungal Activity against Candida albicans: A Systematic Review

Author(s):

Hsuan Hsu, Chirag C. Sheth and Veronica Veses*   Pages 1 - 28 ( 28 )

Abstract:


Background: In the era of antimicrobial resistance, fungal pathogens are not an exception. Several strategies, including antimicrobial stewardship programs and high throughput screening of new drugs are being implemented. Several recent studies have demonstrated effectiveness of plant compounds with antifungal activity.

Objective: In this systematic review we examine the use of natural compounds as a possible avenue to fight fungal infections produced by Candida albicans, the most common human fungal pathogen.

Method: Electronic literature searches were conducted through PubMed/MEDLINE, Cochrane, and Science Direct limited to the 5 years. A total of 131 articles were included with 186 plants extracts evaluated.

Results: Although the majority of the natural extracts exhibited antifungal activities against C. albicans (both in vivo and in vitro), the strongest antifungal activity was obtained from Lawsonia inermis, Pelargonium graveolens, Camellia sinensis, Mentha piperita, and Citrus latifolia.

Conclusion: The main components with proven antifungal activities were phenolic compounds such as gallic acid, thymol, and flavonoids (specially catechin), polyphenols such as tannins, terpenoids and saponins. The incorporation of nanotechnology enhances greatly the antifungal properties of these natural compounds. Further research is needed to fully characterize the composition of all herbal extracts with antifungal activity as well as the mechanisms of action of the active compounds.

Keywords:

herbal extracts, antifungal properties, Candida albicans, gallic acid, thymol, catechin, nanotechnology

Affiliation:

Department of Dentistry, Faculty of Health Sciences, Universidad Cardenal Herrera, CEU Universities, Moncada 46113, Valencia, Department of Medicine, Faculty of Health Sciences, Universidad Cardenal Herrera, CEU Universities, Moncada 46113, Valencia, Department of Biomedical Sciences, Faculty of Health Sciences, Universidad Cardenal Herrera, CEU Universities, Moncada 46113, Valencia



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