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Association of Micro RNA and Postoperative Cognitive Dysfunction: A Review

Author(s):

Noor Anisah Abu Yazit*, Norsham Juliana, Srijit Das, Nor Islami Mohd Fahmi Teng, Nadia Effendy, Sahar Azmani and Suhaini Kadiman   Pages 1 - 10 ( 10 )

Abstract:


Postoperative Cognitive Dysfunction (POCD) refers to the condition of neurocognitive decline following a surgery in a cognitive and sensory manner. There are several risk factors, which may be life-threatening for this condition. Neuropsychological assessment of this condition is very important. In the present review, we discuss the association of apolipoprotein epsilon 4 (APOE ε4) and few miRNAs with POCD, and highlight the clinical importance for prognosis, diagnosis and treatment of POCD. Microarray is a genome analysis that can be used to determine DNA abnormalities. This current technique is rapid, efficient and high-throughout. Microarray techniques are widely used to diagnose diseases, particularly in genetic disorder, chromosomal abnormalities, mutations, infectious diseases and disease-relevant biomarkers. MicroRNAs (miRNAs) are a class of noncoding RNA that are widely found distributed in eukaryotes. Few miRNAs influence the nervous system development, and nerve damage repair. Microarray approach can be utilized to understand the miRNAs involved and its pathways in POCD development, unleashing its potential to be considered as a diagnostic marker for POCD. This paper summarizes and identifies the studies that use microarray based approaches for POCD analysis. Since the application of microarray in POCD is expanding, there is a need to review the current knowledge of this approach.

Keywords:

miRNA, POCD, cognitive, function, treatment, microarray.

Affiliation:

Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Nilai, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Nilai, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Universiti Teknologi MARA, Puncak Alam, Selangor, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Nilai, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Nilai, National Heart Institute, Kuala Lumpur



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