Gabriela L. Borosky* and Kenneth K. Laali* Pages 1543 - 1558 ( 16 )
Despite a huge body of research in the past two decades investigating the antioxidant, antiinflammatory, anti-microbial, and anti-carcinogenic properties of curcumin (CUR), a CUR-based antitumor drug is yet to be developed. Lack of success in achieving this goal stems from CURâ€™s unfavorable biophysicochemical features, particularly poor solubility, low bioavailability, and rapid metabolism, coupled with a complex biological profile making it difficult to determine its mechanism of action. A significant body of literature aimed at improving its physicochemical properties through synthesis or by designing delivery methods has been published, and the progress in these areas has been reviewed. The present review aims to summarize recent progress in the synthesis of structurally diverse â€ścurcumin-inspiredâ€ť compounds along with computational docking and bioassay studies, through which a number of promising analogs have been identified that warrant further study.
New synthetic curcuminoids, biological activity, molecular docking, drug design, protein inhibitors, anticarcinogens.
INFIQC, CONICET and Departamento de QuĂmica TeĂłrica y Computacional, Facultad de Ciencias QuĂmicas, Universidad Nacional de CĂłrdoba, Ciudad Universitaria, CĂłrdoba 5000, Department of Chemistry, University of North Florida, 1 UNF Drive, Jacksonville, Florida 32224