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Psoralen: A Biologically Important Coumarin with Emerging Applications

Author(s):

Abhinay Thakur, Rohit Sharma, Vivek Sheel Jaswal, Eugenie Nepovimova, Ashun Chaudhary and Kamil Kuca*   Pages 1 - 8 ( 8 )

Abstract:


Coumarin has a place with a class of lactones which are fundamentally comprising of a benzene ring fused to αpyrone ring, known as benzopyrones. It likewise has a conjugated framework with electron rich and good charge-transport properties. It is delivered by plants to shield themselves from predation as a chemical response. Despite the fact that, coumarins have been utilized in different products like cosmetics, additives, perfumes, aroma enhancers in various tobaccos and some alcoholic drinks their most relevant role in natural products, organic and medicinal chemistry. Besides, as medicinal candidates a lot of coumarin compounds with strong pharmacological activity and low toxicity and high bioavailability and better curative effects, etc. has been used to treat various types of diseases.Various endeavors have been done to create coumarin-based anticoagulant, antimicrobial, antioxidant, anticancer, anti-diabetic, anti-neurodegenerative, analgesic and anti-inflammatory agents. A class of chemical compounds called as furocoumarins having phototoxic properties found in nature synthesized by plants by fusion of coumarin to a furan ring in different plant species. Psoralens belong to the furocoumarin class which occurs naturally in various plants e.g. lemons, limes, and parsnips. Angelicin is one of the isomers of psoralens and generally most of the furocoumarins are derivatives of psoralens or angelicin. e.g. xanthotoxin, bergapten, and nodekenetin. The present work demonstrated that Psoralen molecules not just have only have anti-tumoral activity against breast cancer yet in addition influence different intracellular signals which maintain high survival of breast cancer cells. Psoralens performs different functions e.g. antagonize metabolic pathways, protease enzymes, cell cycle progression and even interfere in the crosslinking between receptors and growth factor mitogenic signaling.

Keywords:

Psoralen, Coumarin, lactones , furocoumarin, drug, multipotent use

Affiliation:

PG Department of Zoology, DAV College Jalandhar-144008, Punjab, Department of Rasashastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, BHU, Varanasi-221005,Uttar Pradesh, Department of Chemistry, S.M.D.R.S.D College of Education, Pathankot -145001, Department of Chemistry, Faculty of Science, University of Hradec Králové, Rokitanskeho 62, 50003 Hradec Králové, Department of Plant Science (Botany), TAB-Shahpur, Central University of Himachal Pradesh, Dharamshala-176215, Department of Chemistry, Faculty of Science, University of Hradec Králové, Rokitanskeho 62, 50003 Hradec Králové



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