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Andrographolide: Synthetic Methods and Biological Activities

[ Vol. 20 , Issue. 16 ]

Author(s):

Meng Hao, Min Lv* and Hui Xu*   Pages 1633 - 1652 ( 20 )

Abstract:


Andrographolide, a labdane diterpenoid, is extracted and isolated from the plants of Andrographis paniculata. Andrographolide and its derivatives exhibited a wide range of biological properties, including anticancer activity, antibacterial activity, hepatoprotective activity, antiinflammatory activity, antiviral activity, antimalarial activity, antidiabetic activity, insecticidal activity, etc. As a continuation, this review aims at giving an overview of the recent advances (from 2015 to 2018) of andrographolide and its derivatives with regard to bioactivities, mechanisms of action, structural modifications, and structure-activity relationships.

Keywords:

Andrographolide, biological activity, mechanism of action, structural modification, structure-activity relationship.

Affiliation:

College of Plant Protection/Chemistry and Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi Province, College of Plant Protection/Chemistry and Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi Province, College of Plant Protection/Chemistry and Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi Province



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