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Advances on the Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships of Cytisine Derivatives

[ Vol. 20 , Issue. 5 ]

Author(s):

Xiaobo Huang and Hui Xu*   Pages 369 - 395 ( 27 )

Abstract:


Cytisine is a quinolizidine alkaloid isolated from various Leguminosae plants. Cytisine and its derivatives exhibit a broad range of biological properties, such as smoking cessation aid, antidepressant, neuroprotective, nootropic, anticancer, antiviral, antiparasitic, antidiabetic, insecticidal, and nematicidal activities. In this review, the progress of cytisine and its derivatives in regard to bioactivities, total synthesis, structural modifications focusing on their N-12 position and lactam ring is reported. Additionally, the structure-activity relationships of cytisine and its derivatives are also discussed.

Keywords:

Cytisine, bioactivities, total synthesis, structural modification, lactam ring, structure-activity relationship.

Affiliation:

Research Institute of Pesticidal Design & Synthesis, College of Plant Protection/College of Chemistry and Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi Province, Research Institute of Pesticidal Design & Synthesis, College of Plant Protection/College of Chemistry and Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi Province



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