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Synthesis and Biological Activity of Hydrazones and Derivatives: A Review

[ Vol. 20 , Issue. 5 ]

Author(s):

Juliana de Oliveira Carneiro Brum*, Tanos Celmar Costa França, Steven R. LaPlante and José Daniel Figueroa Villar   Pages 342 - 368 ( 27 )

Abstract:


Hydrazones and their derivatives are very important compounds in medicinal chemistry due to their reported biological activity for the treatment of several diseases, like Alzheimer’s, cancer, inflammation, and leishmaniasis. However, most of the investigations on hydrazones available in literature today are directed to the synthesis of these molecules with little discussion available on their biological activities. With the purpose of bringing lights into this issue, we performed a revision of the literature and wrote this review based on some of the most current research reports of hydrazones and derivatives, making it clear that the synthesis of these molecules can lead to new drug prototypes. Our goal is to encourage more studies focused on the synthesis and evaluation of new hydrazones, as a contribution to the development of potential new drugs for the treatment of various diseases.

Keywords:

Hydrazones, guanylhydrazones, biologic activity, medicinal chemistry, Alzheimer’s, cancer, leishmaniasis.

Affiliation:

Medicinal Chemistry Group, Department of Chemistry, Military Institute of Engineering, Praça General Tibúrcio 80, 22290-270, Rio de Janeiro, RJ, Laboratory of Molecular Modeling Applied to the Chemical and Biological Defense (LMCBD), Military Institute of Engineering, Praça General Tibúrcio 80, 22290-270, Rio de Janeiro, RJ, Université du Quebec, INRS-Centre Armand-Frapier Santé Biotechnologie, 531, Boulevard de Praires, Laval H7V 1B7, Medicinal Chemistry Group, Department of Chemistry, Military Institute of Engineering, Praça General Tibúrcio 80, 22290-270, Rio de Janeiro, RJ



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