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Therapeutic Potential of Cinnoline Core: A Comprehensive Review

[ Vol. 20 , Issue. 3 ]

Author(s):

Rajiv K. Tonk*, Sandhya Bawa and Deepak Kumar   Pages 196 - 218 ( 23 )

Abstract:


Cinnoline or Benzo-pyridazine has its place in the family of fairly well-known benzfuseddiazine heterocycles. Because of its natural occurrence and synthetic exploration, cinnoline compounds validated its thought-provoking bioactivity through a number of research publications and patents during the last few decades. A creative consideration has been rewarded to the synthesis of cinnoline based heterocyclic compounds, mostly due to their wide range of diverse pharmacological activities. The present review covers almost all biological properties of 115 cinnoline derivatives reported during the last 65 years from the natural and synthetic origin with 132 references.

Keywords:

Cinnoline, patents, antibacterial, antifungal, anti-inflammatory, analgesic, anticancer, Alzheimer`s disease, parkinson`s disease, antihypertensive, anti-allergic, antihistaminic, antiplatelet, neuroleptic, anti-psychotic.

Affiliation:

Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi- 110017, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi- 110 062, Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences Shoolini University, Solan-173212



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