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Chemistry, Analysis, Pharmacokinetics and Pharmacodynamics Aspects of Lorcaserin, a Selective Serotonin 5-HT2C Receptor Agonist: An Update

Author(s):

Sanjay Sharma *, Komal S. Aware, Ketan Hatware and Kiran Patil   Pages 1 - 11 ( 11 )

Abstract:


This review refers to the all-inclusive details of Lorcaserin Hydrochloride, on comprehensive information about synthesis, analytical methods, pharmacodynamics, pharmacokinetics, drug interaction, and adverse effect. Lorcaserin Hydrochloride is (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride chemically. Lorcaserin HCl is a novel synthetic, centrally acting selective serotonin C (5-HT2c) receptor, l agonist, which results in increased satiety and decreased food consumption in patients. A headache, dizziness, nausea, is the most common side effects associated with this drug. Lorcaserin HCl has two major metabolites, one conjugated with glucuronide called N-carbamoyl glucuronide which is excreted in urine and the second Lorcaserin N-sulfamate which is circulated in the blood. Lorcaserin HCl is synthesized using four different schemes of which a six-step method that resulted in 92.3% yield with 99.8% of purity is employed for scale up production. It is analyzed quantitatively in plasma and brain tissue matrix of rat by Ultra Performance Liquid chromatographic (UPLC) method using MS-MS (Mass Spectrometric) detection.

Keywords:

Lorcaserin Hydrochloride, Appetite suppressant, Chemistry, Analysis, Pharmacokinetics, Pharmacodynamics.

Affiliation:

Quality Assurance, School of Pharmacy and Technology Management, NMIMS, Shirpur, Quality Assurance, School of Pharmacy and Technology Management, NMIMS, Shirpur, Pharmacology, School of Pharmacy and Technology Management, NMIMS, Shirpur, Pharmaceutics, School of Pharmacy and Technology Management, NMIMS, Shirpur



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