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A Review on the Antitumor Activity of Various Nitrogenous-based Heterocyclic Compounds as NSCLC Inhibitors

Author(s):

Jia-Chun Liu, Suresh Narva, Kang Zhou and Wen Zhang*  

Abstract:


At present, cancers have been causing deadly fears to humans and previously incogitable losses to health. Especially, lung cancer is one of the most common causes of cancer-related mortality accounting for approximately 15% of all cancer cases worldwide. While non-small cell lung carcinomas (NSCLCs) makes up to 80% of lung cancer cases. The patient compliance has been weakening because of serious drug resistance and adverse drug effects. Therefore there is an urgent need for the development of novel structural agents to inhibit NSCLCs. Nitrogen-containing heterocyclic compounds exhibit wide range of biological properties, especially antitumor activity. We review some deadly defects of clinical medicines to therapy for the lung cancer and importance of nitrogen based heterocyclic derivatives in drug researches for NSCLCs. Nitrogen heterocycles have significant antitumor activity and various mechanisms for NSCLCs. Nitrogen heterocyclic hybrids could be developed as multi-target-directed NSCLC inhibitors and it is believed that the review is significance for rational designs and new ideas in the development of nitrogen heterocyclic-based drugs.

Keywords:

Anti tumor, Lung cancer, Drug resistance, Nitrogen heterocyclic compounds, NSCLC inhibitors.

Affiliation:

Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014



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