Submit Manuscript  

Article Details


Bioactive Compounds from Seaweed with Anti-Leukemic Activity: A Mini-Review on Carotenoids and Phlorotannins

Author(s):

Tânia P. Almeida, Alice A. Ramos, Joana Ferreira, Amaya Azqueta and Eduardo Rocha*   Pages 1 - 14 ( 14 )

Abstract:


Chronic myeloid leukemia (CML) represents 15 - 20% of all new cases of leukemia and is characterized by an uncontrolled proliferation of abnormal myeloid cells. Currently, the first-line of treatment involves tyrosine kinase inhibitors (TKIs), which specifically inhibits the activity of the fusion protein BCR-ABL. However, resistance, mainly due to mutations, can occur. In the attempt to find more effective and less toxic therapies, several approaches are taken into consideration such as research of new anti-leukemic drugs and “combination chemotherapy” where different drugs that act by different mechanisms are used. Here, we reviewed the molecular mechanisms of CML, the main mechanisms of drug resistance and current strategies to enhance the therapeutic effect of TKIs in CML. Despite major advances in CML treatment, new, more potent anticancer drugs and with fewer side effects are needed. Marine organisms, and particularly seaweed, have a high diversity of bioactive compounds some of them with anticancer activity in several in vitro and in vivo models. The state-of-art suggests that their use during cancer treatment may improve the outcome. We reviewed here the yet few data supporting anti-leukemic activity of some carotenoids and phlorotannins in some leukemia models. Also, strategies to overcome drug resistance are discussed, particularly the combination of conventional drugs with natural compounds.

Keywords:

Carotenoids, Imatinib, Leukemia, Seaweed, Phlorotannins

Affiliation:

Team of Histomorphology, Physiopathology and Applied Toxicology, CIIMAR/CIMAR – Interdisciplinary Center for Marine and Environmental Research, U.Porto – University of Porto, Avenida General Norton de Matos s/n, 4450-208 Matosinhos, Team of Histomorphology, Physiopathology and Applied Toxicology, CIIMAR/CIMAR – Interdisciplinary Center for Marine and Environmental Research, U.Porto – University of Porto, Avenida General Norton de Matos s/n, 4450-208 Matosinhos, Team of Histomorphology, Physiopathology and Applied Toxicology, CIIMAR/CIMAR – Interdisciplinary Center for Marine and Environmental Research, U.Porto – University of Porto, Avenida General Norton de Matos s/n, 4450-208 Matosinhos, Department of Pharmacology and Toxicology, University of Navarra, C/ Irunlarrea 1, CP 31008 Pamplona, Navarrasp, Team of Histomorphology, Physiopathology and Applied Toxicology, CIIMAR/CIMAR – Interdisciplinary Center for Marine and Environmental Research, U.Porto – University of Porto, Avenida General Norton de Matos s/n, 4450-208 Matosinhos



Read Full-Text article