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Correlation between in vitro and in vivo Data of Radiolabeled Peptide for Tumor Targeting

[ Vol. 19 , Issue. 12 ]

Author(s):

Soghra Farzipour and Seyed Jalal Hosseinimehr*   Pages 950 - 960 ( 11 )

Abstract:


Tumor-targeting peptides have been generally developed for the overexpression of tumor specific receptors in cancer cells. The use of specific radiolabeled peptide allows tumor visualization by single photon emission computed tomography (SPECT) and positron emission tomography (PET) tools. The high affinity and specific binding of radiolabeled peptide are focusing on tumoral receptors. The character of the peptide itself, in particular, its complex molecular structure and behaviors influence on its specific interaction with receptors which are overexpressed in tumor. This review summarizes various strategies which are applied for the expansion of radiolabeled peptides for tumor targeting based on in vitro and in vivo specific tumor data and then their data were compared to find any correlation between these experiments. With a careful look at previous studies, it can be found that in vitro unblock-block ratio was unable to correlate the tumor to muscle ratio and the success of radiolabeled peptide for in vivo tumor targeting. The introduction of modifiers’ approaches, nature of peptides, and type of chelators and co-ligands have mixed effect on the in vitro and in vivo specificity of radiolabeled peptides.

Keywords:

Radiopharmaceutical, 99mTc, peptide, radiolabeled, tumor, SPECT.

Affiliation:

Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari

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