Yuanyuan Zhang, Junhong Liu*, Dayong Shi* and Zheng Li Pages 1204 - 1218 ( 15 )
As important marine biological resources, corals produce a large amount of active organic compounds in their secondary metabolic processes, including numerous brominated, chlorinated, and iodinated compounds. These compounds, with novel structures and unique activities, guide the discovery and research of important lead compounds and novel biological mechanisms. Through a large number of literature surveys, this paper summarized a total of 145 halogenated secondary metabolites which were roughly divided into four major classes of terpenes, prostaglandins, steroids and alkaloids, and they were mainly isolated from ten coral families, Ellisellidae, Gorgoniidae, Briareidae, Plexauridae, Anthothelidae, Alcyoniidae, Clavularidae, Tubiporidae, Nephtheidae and Dendrophyllidae to the best of our knowledge. In addition, their organism species, structure composition and biological activity were also discussed in the form of a chart in this essay.
Marine, corals, metabolites, halogenated, bioactivity, chemical diversity.
Department of Pharmaceutics, Qingdao University of Science and Technology, Qingdao 266042, Department of Pharmaceutics, Qingdao University of Science and Technology, Qingdao 266042, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, Department of Pharmaceutics, Qingdao University of Science and Technology, Qingdao 266042