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Insulin-like Growth Factor I Receptor: A Novel Target for Hepatocellular Carcinoma Gene Therapy

[ Vol. 19 , Issue. 4 ]

Author(s):

Li Wang, Min Yao, Wenjie Zheng, Miao Fang, Mengna Wu, Jianying Sun, Zhizhen Dong* and Dengfu Yao*   Pages 272 - 280 ( 9 )

Abstract:


Human insulin-like growth factor (IGF) axis affects the molecular pathogenesis of hepatocellular carcinoma (HCC), especially in the abnormality of hepatic IGF-I receptor (IGF-IR) or IGF-II expression as a key molecule in hepatocarcinogenesis. However, the over-expression of hepatic IGFIR is associated with HCC progression with largely unknown mechanisms. The IGF-IR as one key molecule of the IGF signal pathway plays an important role in the hepatocyte malignant transformation. Attaching importance to IGF-IR might improve the prognostic or the therapeutic technique of HCC. This article reviews IGF-IR alteration during HCC development, and the effects of silencing IGF-IR gene by specific short hairpin RNA on the inhibition of cell proliferation in vitro or HCC xenograft growth in vivo to elucidate it as a novel molecular-targeted therapy for HCC.

Keywords:

Hepatocellular carcinoma, insulin-like growth factor-I receptor, molecular targeted, gene therapy, gene amplification, xenograft tumor, cell proliferation.

Affiliation:

Medical School of Nantong University, Nantong 226001, Medical School of Nantong University, Nantong 226001, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, Department of Oncology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, Department of Oncology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, Department of Oncology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, Medical School of Nantong University, Nantong 226001, Medical School of Nantong University, Nantong 226001

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