Emiliya V. Nosova*, Galina N. Lipunova, Valery N. Charushin and Oleg N. Chupakhin Pages 999 - 1014 ( 16 )
Tuberculosis (TB) takes the second place among the reasons for mortality from infectious diseases. For this reason, the problem of tuberculosis treatment requires urgent attention all over the world. Some 2-amino substituted 1,3-benzothiazin-4-ones (2-amino-1,3-BTZs) represent a promising new class of antitubercular agents. Other 1,3-benzothiazin-4-one derivatives, mostly 2-aryl and 2(pyridin-2-yl) ones, are attractive due to their ability to suppress oxidative stress-induced cardiomyocyte apoptosis. This review covers the synthetic approaches to 2-amino- and 2-aryl(heteryl) substituted 1,3-benzothiazin-4-ones (1,3-BTZs). A brief overview of structure-activity relationships is presented.
Antitubercular agent, 1, 3-Benzothiazin-4-one, Cyclocondensation, 2-Mercaptobenzoic acid, 2-Halogenobenzoyl isothiocyanate, apoprosis.
Ural Federal University, Postovsky Institute of Organic Synthesis Ekaterinburg, Postovsky Institute of Organic Synthesis Ekaterinburg, Postovsky Institute of Organic Synthesis Ekaterinburg