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Benzamide and Benzamidine Compounds as New Inhibitors of Urokinasetype Plasminogen Activators

[ Vol. 18 , Issue. 20 ]

Author(s):

Canan Kuş*, Ezgi Özer, Yeşim Korkmaz, Erkan Yurtcu and Rukiye Dağalp   Pages 1753 - 1758 ( 6 )

Abstract:


Background & Method: In this ongoing research, it is aimed to investigate the synthesis, structure identification and effects on urokinase-type plasminogen activators (uPA) and its receptor levels of 4-(3H-imidazo[4,5-b]pyridin-2-yl)-N-substituted benzamide and benzamidine derivatives. uPA levels obtained from 4b and 7d administration were similar to 5-FU (5-fluorouracil) for colorectal carcinoma cells (p<0.05). 4b and 7d significantly reduced uPAR (urokinase-type plasminogen activator receptor) levels on both cell lines (p<0.05).

Conclusion: uPAR levels obtaining from 4b and 7d administration were similar to 5-FU for both cell lines colorectal (Colo205, CCL-222) and hepatocellular (HepG2, CCL-23) carcinoma cells (p<0.05).

Keywords:

Imidazopyridine, benzamide, benzamidine, urinary plasminogen activator, uPAR, upamostat.

Affiliation:

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100-Tandogan, Ankara, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100-Tandogan, Ankara, Department of Medical Biology, Faculty of Medicine, Baskent University, Ankara, Department of Medical Biology, Faculty of Medicine, Baskent University, Ankara, Department of Statistics, Faculty of Science, Ankara University, 06100-Tandogan, Ankara

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