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Ultrasound-assisted Synthesis of 6-substituted indolo[2,3-b]quinolines: their Evaluation as Potential Cytotoxic Agents

[ Vol. 19 , Issue. 7 ]

Author(s):

Nagaraju Marepu, Mahesh Gosi, Santhoshi Sumana Vedula, Sunandamma Yeturu* and Manojit Pal*   Pages 599 - 608 ( 10 )

Abstract:


Background: The indolo[2,3-b]quinoline framework is often found in various natural products displaying a range of pharmacological activities. This is an attractive template for the design and discovery of potential drugs especially for the identification of new anticancer agents.

Methods: The synthesis of 6-substituted indolo[2,3-b]quinolones was undertaken and carried out using a ultrasound assisted method involving two sequential C-N bond forming reactions between 3-(2- bromophenyl)-2-chloroquinoline and amines in a single pot in the presence of Pd(OAc)2 and a ligand (S)-BINAP. All the synthesized compounds were tested in vitro against two cancer cell lines e.g. MCF7 and HepG2 along with non-cancerous HEK293 cell lines.

Results: Two of these compounds showed promising and selective growth inhibition of MCF7 cell lines and one induced significant apoptosis in cancer (MCF7) cells.

Conclusion: Compounds based on indolo[2,3-b]quinolone framework may be useful for the identification of new cytotoxic agents thereby potential cure for breast cancer.

Keywords:

Indolo[2, 3-b]quinoline, palladium, coupling, ultrasound, cytotoxicity, cancer cells.

Affiliation:

Department of Chemistry, Acharya Nagarjuna University, Nagarjunanagar, Guntur-522510, Department of Chemistry, Acharya Nagarjuna University, Nagarjunanagar, Guntur-522510, Department of Chemistry, Acharya Nagarjuna University, Nagarjunanagar, Guntur-522510, Department of Chemistry, Acharya Nagarjuna University, Nagarjunanagar, Guntur-522510, Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046

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