Submit Manuscript  

Article Details


Medicinal Importance of Azo and Hippuric Acid Derivatives

[ Vol. 19 , Issue. 9 ]

Author(s):

Tehreem Tahir, Muhammad Ashfaq*, Humna Asghar, Mirza I. Shahzad, Rukhsana Tabassum and Areeba Ashfaq   Pages 708 - 719 ( 12 )

Abstract:


In this review, specific therapeutic and medicinal advantages including antiviral, antibacterial, antifungal and antitumor, strategies for drug designing, structure-activity relationship, advances in the syntheses of azo and hippuric acid derivatives of more than 50 compounds have been discussed since 2009-2018. It is found that phenyl-diazenyl azo derivatives and pyridinyl substituted hippuric acid derivatives showed promising antiretroviral potential. The incorporation of azo functionality to the respective quinolones and coumarin moieties and the insertion of thiocarbazone to hippuric acid displayed immense antibacterial activities. While, azo and hippuric acid derivatives of triazole and phenyl species gave maximum fungicidal as well as cytotoxic activities.

Keywords:

Drug targets, azo dyes, hippuric acid derivatives, synthetic chemistry, antiviral drugs, anti-microbial agents.

Affiliation:

Department of Biochemistry and Biotechnology, Faculty of Science, The Islamia University of Bahawalpur, Bahawalpur 63100, Department of Biochemistry and Biotechnology, Faculty of Science, The Islamia University of Bahawalpur, Bahawalpur 63100, Department of Biochemistry and Biotechnology, Faculty of Science, The Islamia University of Bahawalpur, Bahawalpur 63100, University College of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Bahawalpur 63100, Department of Chemistry, Faculty of Science, The Islamia University of Bahawalpur, Bahawalpur 63100, Bahawal Victoria Hospital, Bahawalpur 63100

Graphical Abstract:



Read Full-Text article