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Ultrasound Assisted Cu-catalyzed Synthesis of 1,2-Disubstituted Benzimidazoles as Potential Antibacterial Agents

[ Vol. 18 , Issue. 14 ]

Author(s):

V. Mallikarjuna Rao, A. Srinivasa Rao*, S. Shobha Rani, S. Yasaswi and Manojit Pal*   Pages 1233 - 1239 ( 7 )

Abstract:


Background: The ultrasound assisted synthesis and anti-bacterial evaluation of a series of compounds based on 1,2-disubstituted benzimidazole framework is reported here. The approach leading to the synthesis of these compounds involved the Cu-catalyzed coupling-cyclization of N-substituted 2-iodoanilines with benzamide derivatives in the presence of 2-aminoethanol as a ligand.

Conclusion: A number of compounds were prepared using this methodology in acceptable yield. Two of these compounds showed promising antibacterial activities when tested against both Gram-positive and Gram-negative bacterial strains.

Keywords:

Benzimidazole, ultrasound, catalyst, antibacterial, Cu-catalyzed, Gram-positive, Gram-negative.

Affiliation:

Medicinal Chemistry Division, GVKBIO Sciences, Pvt, Lt, IDA Nacharam, Hyderabad-500076, Telangana, Shri Vishnu College of Pharmacy, Bhimavaram-534202, West Godawari District, Andhra Pradesh, Centre for Pharmaceutical Sciences, IST, Jawaharlal Nehru Technological University, Hyderabad-500085, Telangana, Medicinal Chemistry Division, GVKBIO Sciences, Pvt, Lt, IDA Nacharam, Hyderabad-500076, Telangana, Dr. Reddy`s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046

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