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Targeting the Microcirculation by Indole-3-carbinol and Its Main Derivate 3,3,’-diindolylmethane: Effects on Angiogenesis, Thrombosis and Inflammation

[ Vol. 18 , Issue. 11 ]

Author(s):

Emmanuel Ampofo*, Beate M. Schmitt, Michael D. Menger and Matthias W. Laschke   Pages 962 - 968 ( 7 )

Abstract:


The pharmacological targeting of microcirculatory dysregulations is a therapeutic strategy for the treatment of numerous pathological conditions, such as cancer, thrombosis and inflammation. A promising candidate for this purpose is indole-3-carbinol (I3C), a phytochemical compound of cruciferous vegetables, and its main derivate 3,3,’-diindolylmethane (DIM). As summarized in this review, I3C and DIM affect multiple molecular and cellular processes within the microcirculation due to their pleiotropic action profile. These include angiogenesis, leukocyte-endothelial cell interaction, cytokine and reactive oxygen species (ROS) production, thrombus formation and microvascular leakage. Hence, I3C may serve as a lead compound for the future chemical synthesis of novel drugs that exert comparable beneficial effects while exhibiting an improved bioavailability.

Keywords:

Angiogenesis, endothelial cells, indole-3-carbinol, inflammation, microcirculation, leukocytes, reactive oxygen species, thrombosis.

Affiliation:

Institute for Clinical & Experimental Surgery, Saarland University, 66421 Homburg/Saar, Institute for Clinical & Experimental Surgery, Saarland University, 66421 Homburg/Saar, Institute for Clinical & Experimental Surgery, Saarland University, 66421 Homburg/Saar, Institute for Clinical & Experimental Surgery, Saarland University, 66421 Homburg/Saar

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