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Anticancer Potential of Thiazole Derivatives: A Retrospective Review

[ Vol. 18 , Issue. 8 ]

Author(s):

Shweta Jain, Satyanarayan Pattnaik, Kamla Pathak, Sushant Kumar, Devender Pathak, Surendra Jain and Ankur Vaidya*   Pages 640 - 655 ( 16 )

Abstract:


This review brings forth the potential of thiazole derivatives for their anticancer activities. The emphasis is placed on the structural diversity of thiazole derivatives, responsible for their specific anticancer activity. Multiple classes of thiazole derivatives such as Schiff base, mono-, di-, tri-, and heterocyclic substituents that possess anticancer activity have been exemplified. Molecular modelling of compounds that predicts enhanced anticancer activity of the modified structures has also been elaborated in the review. Significant advancements in synthetic chemistry related to cytotoxicity can now better position the drug discovery team to undertake thiazoles as valuable leads. The beneficial thiazole derivatives possessing anticancer activity will reignite the interest of medicinal chemists in thiazole and their derivatives.

Keywords:

Anticancer, biological activity, HIV, thiazole, thiazole derivatives, structure-activity relationship.

Affiliation:

Department of Pharmacy, Dr. H.S. Gour University, Sagar (M.P.) 470003, Pharmacy College, Uttar Pradesh University of Medical Sciences, Saifai, Etawah (U.P.) 206130, Pharmacy College, Uttar Pradesh University of Medical Sciences, Saifai, Etawah (U.P.) 206130, Pharmacy College, Uttar Pradesh University of Medical Sciences, Saifai, Etawah (U.P.) 206130, Pharmacy College, Uttar Pradesh University of Medical Sciences, Saifai, Etawah (U.P.) 206130, National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Mississippi, MS-38677, Pharmacy College, Uttar Pradesh University of Medical Sciences, Saifai, Etawah (U.P.) 206130

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