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Aptamer Oligonucleotides as Potential Therapeutics in Hematologic Diseases

[ Vol. 19 , Issue. 10 ]

Author(s):

Weibin Li, Meng Zhao, Kaiyu Wang, Huihui Yan and XIaopeng lan*   Pages 788 - 795 ( 8 )

Abstract:


Background & Objective: Aptamers are single-stranded DNA or RNA oligonucleotides generated by a novel in vitro selection technique termed Systematic evolution of ligands by exponential enrichment (SELEX). During the past two decades, various aptamer drugs have been developed and many of them have entered into clinical trials.

Conclusion: In the present review, we focus on aptamers as potential therapeutics for hematological diseases, including anemia of chronic inflammation (ACI) and anemia of chronic disease (ACD), hemophilia, thrombotic thrombocytopenic purpura (TTP) or VWD type-2B, and sickle cell disease (SCD), in particular, those that have entered into clinical trials.

Keywords:

Aptamer, anemia, hemophilia, thrombotic thrombocytopenic purpura, VWD type-2B, sickle cell disease.

Affiliation:

Fuzhou General Hospital, Second Military Medical University - Institute for Laboratory Medicine fuzhou, Fuzhou General Hospital, Second Military Medical University - Institute for Laboratory Medicine fuzhou, Fuzhou General Hospital - Institute for Laboratory Medicine fuzhou, Fuzhou General Hospital, Second Military Medical University - Institute for Laboratory Medicine fuzhou, Fuzhou General Hospital, Second Military Medical University - Institute for Laboratory Medicine fuzhou



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