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Synthesis of New Bis-Spiropyrazoles as Antitumor Agents under Ultrasound Irradiation

[ Vol. 18 , Issue. 7 ]

Author(s):

Naglaa A. Abdel Hafez, Huwaida M.E. Hassaneen, Thoraya A. Farghaly*, Sayed M. Riyadh and Heba S.A. Elzahabi   Pages 631 - 637 ( 7 )

Abstract:


Objective and Background: Hydrazonoyl halides were used as precursors for the synthesis of a new series of bis-spiropyrazoles via reaction with 3,5-diarylidene-piperidone derivatives under ultrasound irradiation. The products were secluded in good yield after short reaction periods.

Conclusion: The anticancer activity of bis-spiropyrazoles against HepG2 (hepatic cancer), A549 (lung cancer) and CaCo2 (colon cancer) cell lines was screened. Three tested compounds 4b, 4c and 4f showed promising activity.

Keywords:

Antitumor activity, Bis-spiropyrazoles, 3, 5-diarylidene-piperidones, hydrazonoyl halides, spiropiperidinecarbinols, ultrasound irradiation.

Affiliation:

Department of Applied Organic Chemistry, National Research Center, Dokki, Cairo, Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al Azhar University, Cairo, 11754

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