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Recent Progress in Biological Activities of Indole and Indole Alkaloids

[ Vol. 18 , Issue. 1 ]

Author(s):

Thokchom Prasanta Singh and Okram Mukherjee Singh*   Pages 9 - 25 ( 17 )

Abstract:


The indole scaffold is found in a wide range of bioactive heterocycles and natural products. Moreover, the indole moiety is considered as the active principle in several alkaloids such as mitomycin C and reserpine. Thus, over the past decade, chemists are increasingly attracted towards the studies on the pharmacological and therapeutic activities of indole containing compounds. Furthermore, the molecular structures of well-known drugs such as sumatriptan, tadalafil, fluvastatin and rizatriptan are based on indole frameworks.

This mini-review covers some of the significant and recent achievements of indole derivatives with respect to their biological activities up to 2015.

Keywords:

Anti-cancer, anti-HIV, anti-microbial, anti-oxidant, biological activities, indole.

Affiliation:

Chemistry Department, Manipur University, Canchipur-795 003, Manipur, Chemistry Department, Manipur University, Canchipur-795 003, Manipur

Graphical Abstract:



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