Submit Manuscript  

Article Details


Synthetic Methods of Quinoline Derivatives as Potent Anticancer Agents

[ Vol. 17 , Issue. 16 ]

Author(s):

Vaibhav Sharma, Dinesh Kumar Mehta* and Rina Das   Pages 1557 - 1572 ( 16 )

Abstract:


Background: On account of significant biological activities, quinoline derivatives have drawn more attention to the synthesis and biological activities in the search for new therapeutic agents. Several new synthetic approaches have been implemented to derive new molecules from quinoline and all the synthesized molecules showed effective anticancer activity.

Method: Some molecules are synthesized using quinolones as precursor reactant, which is another effective product of quinoline, also showing significant activity against malignant tumors. The presence of nitrogen in it and its ability to bind with enzymes like gyrase, topoisomerase II and kinase have also proven it with antitumor activity.

Conclusion: This review encapsulates the recent advances in the synthesis and anticancer activity of Quinoline derivatives.

Keywords:

Anticancer, anti-inflammatory, cancer, compounds, heterocyclic, quinoline, tumour.

Affiliation:

M.M. College of Pharmacy, M.M. University, Mullana-Ambala, Hr-133207, M.M. College of Pharmacy, M.M. University, Mullana-Ambala, Hr-133207, M.M. College of Pharmacy, M.M. University, Mullana-Ambala, Hr-133207

Graphical Abstract:



Read Full-Text article