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Characterization of a Novel Polysaccharide-Iron(III) Complex and Its Anti-Anemia and Nonspecific Immune Regulating Activities

[ Vol. 17 , Issue. 17 ]

Author(s):

Yun Zhang, Fanyi Ma, Jinhua Zhu, Zuliang Du, Ying-Yong Zhao and Xiuhua Liu*   Pages 1677 - 1683 ( 7 )

Abstract:


Objective: Dioscorea opposita Thunb is the famous food and traditional medicine in China and it was rich in polysaccharides. Polysaccharides of Dioscorea Opposita Thunb possess immunoregulatory activity, free radical scavenging activity and anti-diabetic activity. A novel polysaccharide- iron(III) complex (CYPIC) was synthesized by using crude polysaccharide extracted from Dioscorea opposita Thunb. The component, structure, morphology and molecular weights of CYPIC were analysed, and the anti-anemia, acute toxicity and nonspecific immune regulating activities of CYPIC were assayed. The results showed that CYPIC could increase red blood cell count (RBC), hemoglobin (Hb), hematocrit (HCT), thymus and spleen index of mice with iron deficiency anemia (IDA). Although the structure and deeper mechanisms of CYPIC should be further studied, CYPIC has the potential to be used as an iron supplement for the treatment of iron deficiency anemia.

Conclusion: The large scale industrial production was suggested due to the simple preparation processing of CYPIC.

Keywords:

Dioscorea opposita Thunb, iron deficiency anemia, iron supplement, polysaccharide, polysaccharide-iron(III) complex.

Affiliation:

Key Laboratory for Special Functional Materials of Ministry of Education, Henan University, address, Kaifeng, 475004, Key Laboratory of Natural Medicine and Immune-Engineering of Henan Province, Henan University, Kaifeng, 475004, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, Key Laboratory for Special Functional Materials of Ministry of Education, Henan University, address, Kaifeng, 475004, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Science, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, Key Lab. of Natural Medicine and Immune-Engineering of Henan Province College of Chemistry and Chemical Engineering Henan University, Kaifeng, 475004

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