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Recent Development of Oridonin Derivatives with Diverse Pharmacological Activities

[ Vol. 19 , Issue. 2 ]

Author(s):

Weiyan Cheng, Chuanhui Huang, Weifeng Ma, Xin Tian* and Xiaojian Zhang*   Pages 114 - 124 ( 11 )

Abstract:


Oridonin is one of the major components isolated from Isodon rubescens, a traditional Chinese medicine, and it has been confirmed to exhibit many kinds of biological activities including anticancer, anti-inflammation, antibacterial and so on. However, the poor pharmaceutical property limits the clinical applications of oridonin. So many strategies have been explored in the purpose of improving the potencies of oridonin, and structure modification is one thus way. This review outlines the landscape of the recent development of oridonin derivatives with diverse pharmacological activities, mainly focusing on the biological properties, structure-activity relationships, and mechanism of actions.

Keywords:

Derivative, mechanism of action, oridonin, pharmaceutical activity, structure modification, structure-activity relationship.

Affiliation:

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Xinyang Vocational and Technical College, Xinyang 464000, Department of Pharmacy, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052

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