Submit Manuscript  

Article Details


Facile and Solvent-free Domino Synthesis of New Quinolidinyl-2,4- thiazolidinones: Antifungal Activity and Molecular Docking

[ Vol. 18 , Issue. 7 ]

Author(s):

Dnyaneshwar D. Subhedar, Mubarak H. Shaikh, Santosh G. Tupe, Mukund V. Deshpande, Vijay M. Khedkar, Prakash C. Jha and Bapurao B. Shingate*   Pages 622 - 630 ( 9 )

Abstract:


Objective: We have synthesized new quinolidinyl-thiazolidinones via Knoevenagel condensation- alkylation reaction, catalyzed by [Et3NH][HSO4]. The present approach offers several advantages such as higher yields, eco-friendly reaction condition and economic availability of the catalyst.

Method: The newly synthesized compounds were evaluated for their in vitro antifungal activity against six fungal strains. Some of the synthesized conjugates displayed good to moderate antifungal activity.

Conclusion: Again, the molecular docking study performed against the fungal sterol 14α-demethylase (CYP51) showed an excellent binding affinity towards the enzyme which could rationalize the promising antifungal activity portrayed by these derivatives and provides a platform for structure based drug design.

Keywords:

Antifungal activity, ionic liquid, molecular docking, multicomponent reaction, 2, 4-thiazolidinones, solvent-free reaction.

Affiliation:

Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004, Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004, Biochemical Sciences Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411 008, Biochemical Sciences Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411 008, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, School of Chemical Sciences, Central University of Gujarat, Sector-30, Gandhinagar, 38200, Gujarat, Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004

Graphical Abstract:



Read Full-Text article