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Synthesis and Evaluation of the Hypoglycemic and Hypolipidemic Activity of Sulfonamide-benzothiazole Derivatives of Benzylidene-2,4- thiazolidnedione

[ Vol. 17 , Issue. 8 ]

Author(s):

Abbas Ahmadi*, Mohsen Khalili, Lida Sohrabi, Nazanin Delzendeh, Babak Nahri-Niknafs and Fariba Ansari   Pages 721 - 726 ( 6 )

Abstract:


Background: Thiazolidinediones (TZDs) and sulfonamides are important and highly consumption class of antidiabetic drugs having insulin sensitizing and stimulating properties in patients with type 2 diabetes, respectively.

Objective: In this paper, some novel benzothiazole derivatives of TZD-sulfonamides were synthesized (I-IV) and evaluated for anti-hyperglycemic and anti-hyperlipidemic activities in the STZ-induced diabetic rat model.

Results: Results indicated that all new conjugated compounds showed significant hypoglycemic activities compared to control animals that were better for I and IV than others. Moreover, these new compounds displayed high efficiency for lowering lipid profiles as compared to control and standard (Pioglitazone) groups that was significant and higher for I than others.

Conclusion: It is concluded that these new conjugated TZD-sulfonamide-benzothiazoles (I-IV) can indicate useful results for hypoglycemic and hypolipidemic activities compared to control and standard groups, respectively with different mechanism that is closer to TZDs' analogs.

Keywords:

Hypoglycemic and hypolipidemic activities, STZ-induced diabetic rat model, Sulfonamide-benzothiazole Derivatives, Thiazolidinediones (TZDs).

Affiliation:

Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, No 99, Yakhchal, Gholhak, Shariati, Tehran, Neurophysiology Research Center, Shahed University, Tehran, Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Department of Physiology, School of Medicine, Shahed University, Tehran



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