Submit Manuscript  

Article Details


An Overview of Neolignans of the Genus Piper L.: Isolation Methods and Biological Activities

[ Vol. 17 , Issue. 8 ]

Author(s):

Arthur Ladeira Macedo, Thais Carvalho Costa dos Santos, Alessandra Leda Valverde, Davyson de Lima Moreira and Thatyana Rocha Alves Vasconcelos*   Pages 693 - 720 ( 28 )

Abstract:


Background: The genus Piper L. has the shikimic acid pathway predominantly expressed, biosynthesizing many cinnamic acid derivatives (CAD).

Objective: Neolignans comprise an important class of CAD that exhibit a wide range of pharmacological properties such as antibacterial, antitumor, insecticidal, anti-inflammatory, antioxidant, smooth muscle relaxant, neuroprotective, antiprotozoal and against platelet aggregation factor. These substances have been extracted and isolated from Piper species using different technics.

Results: The present review aims to summarize extraction and isolation methods and biological activities of the different types of neolignans covering the period from 1968 to January 2016.

Keywords:

Biological activity, extraction, isolation, natural products, neolignans, Piper, Piperaceae.

Affiliation:

Departamento de Quimica Organica, Instituto de Quimica, Universidade Federal Fluminense, Niteroi, Departamento de Quimica Organica, Instituto de Quimica, Universidade Federal Fluminense, Niteroi, Departamento de Quimica Organica, Instituto de Quimica, Universidade Federal Fluminense, Niteroi, Departamento de Produtos Naturais, Instituto de Tecnologia em Farmacos, Fundacao Oswaldo Cruz, Rio de Janeiro, Departmento de Quimica Organica, Instituto de Quimica, Universidade Federal Fluminense, CEP: 24020-141, Niteroi



Read Full-Text article