Alessia Di Silvestre, Marianna Lucafo, Sara De Iudicibus, Alessandro Ventura, Stefano Martelossi, Gabriele Stocco and Giuliana Decorti* Pages 657 - 666 ( 10 )
Background: Glucocorticoids (GCs) are largely used in different inflammatory, autoimmune and proliferative diseases. To date their mechanism of action is not completely clear and more studies are necessary, in particular to explain the great interindividual variability in clinical response. In this panorama the glucocorticoid receptor (GR) has an important role: in fact it regulates the pharmacological response thanks to the capability to interact with different molecules (DNA, RNA, ncRNA and proteins) that are known to influence its activity.Results: In this review our aim is to highlight the knowledge about the role of protein-protein, RNAprotein interactions and epigenetic modifications on the GR and the consequent response to GCs. The characteristics of these interactions with the GR and their effects on the pharmacological activity of GCs will be examined. Conclusion: This information could contribute to the prediction of individual sensitivity to steroids through the identification of new markers of GC resistance. In addition this knowledge may be used in developing new strategies for targeted therapy.
Biomarkers, epigenetic, glucocorticoid, glucocorticoid receptor, protein-protein interactions, RNA-protein interactions, sensitivity.
PhD School in Science of Reproduction and Development, University of Trieste, Trieste, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Department of Life Sciences, University of Trieste, Trieste, Department of Life Sciences, University of Trieste, Via Alexander Fleming, 22, 34127 Trieste