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Plastid Molecular Pharming I. Production of Oral Vaccines via Plastid Transformation

[ Vol. 17 , Issue. 13 ]

Author(s):

Bernadett Berecz, Helga Zelenyánszki, Sára Pólya, Cecília Tamás-Nyitrai and Mária Oszvald   Pages 1292 - 1315 ( 24 )

Abstract:


Background: Vaccines produced in plants have opened up new opportunities in vaccination.

Objective: Among the various categories of vaccines, the recombinant vaccine is generally regarded as the most economical and safest type because it cannot cause disease and does not require large-scale cultivation of pathogens. Due to the low cost of their cultivation, plants may represent viable alternative platforms for producing subunit vaccines. Genetic engineering of plastids is the innovation of the last three decades and has numerous benefits when compared to nuclear transformation. Due to the high level of expression, oral vaccines produced in transplastomic plants do not have to be purified as they can be consumed raw, which, therefore, reduces the cost of preparation, transportation and handling of the vaccines. Oral vaccination also excludes the risk of other infections or contaminations, while compartmentation of the plant cell provides an excellent encapsulation to the antigen within the plastid.

Results & Conclusion: Herein we review the main biotechnological and immunological aspects of the progress achieved in the field of plastid derived edible vaccines during the last decade. As there is a public debate against genetically modified crops, the advantages and limitations of oral vaccines are also discussed.

Keywords:

Genetic engineering, molecular pharming, oral vaccine, plastid biotechnology, plastid transformation, transplastomic plants.

Affiliation:

Department of Plant Physiology and Molecular Plant Biology, Eötvös Loránd University, Pázmány Péter sétány 1/C., Budapest, H-1117, Deparment of Plant Physiology and Molecular Plant Biology, Eötvös Loránd University, Budapest, Deparment of Plant Physiology and Molecular Plant Biology, Eötvös Loránd University, Budapest, Institute of Media Technology and Light Industry Engineering, Óbuda University, Budapest, Deparment of Plant Physiology and Molecular Plant Biology, Eötvös Loránd University, Budapest

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