Xiaoli Zhang, Jiyong Wu and Yepeng Luan* Pages 675 - 682 ( 8 )
Background: Tip60, the founding member of MYST histone acetyltransferase family, was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. Tip60 plays roles in many processes such as cellular signaling transmission, DNA damage repair, cell cycle and checkpoint control and apoptosis by acetylating its histone or non-histone substrates.Results: Dysfunction of Tip60 could promote or suppress diseases including different kinds of cancers. Conclusion: Here, main functions and its known inhibitors were summarized.
Cancer, ε-amino, HATs, HDACs, histone acetyltransferase, inhibitor, Tip60.
Department of Pharmacy, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, Department of Pharmacy, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, Department of Medicinal Chemistry, School of Pharmacy, Qingdao University, Qingdao, Shandong Province