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Spirooxindoles as Potential Pharmacophores

[ Vol. 17 , Issue. 16 ]

Author(s):

Siva S. Panda, Rachel A. Jones, Praveen Bachawala and Prabhu P. Mohapatra   Pages 1515 - 1536 ( 22 )

Abstract:


Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent.

Background: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.

This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities.

Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.

Keywords:

Biological importance, chemistry, heterocycles, pharmacophores, spirooxindoles, synthesis.

Affiliation:

Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, Center for Heterocyclic Compounds, University of Florida, Department of Chemistry, Gainesville, Florida 32611-7200, MilliporeSigma Pvt. Ltd., Isotec Division, Miamisburg, OH 45342, Department of Chemistry & Physics, Augusta University, Augusta, GA 30912

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