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Anticancer Activity and Modes of Action of (arene) ruthenium(II) Complexes Coordinated to C-, N-, and O-ligands

[ Vol. 16 , Issue. 10 ]

Author(s):

Bernhard Biersack   Pages 804 - 814 ( 11 )

Abstract:


An overview of anticancer active (arene)ruthenium(II) complexes coordinated to period 2 element-based ligand systems, i.e., carbon-, nitrogen-, and oxygen-coordinated ligands, is provided in this mini-review. A bridge is forged from the large group of anticancer active ruthenium compounds with monodentate and chelating nitrogen ligands via complexes of O,O-chelating ligands to organometallic ruthenium derivatives coordinated to carbon. (Arene)ruthenium(II) complexes with reduced side-effects and enhanced efficacy against cancer are highlighted. Pertinent literature is covered up to 2014.

Keywords:

Anticancer drugs, (Arene)Ru(II), DNA binding, Metastasis, Organometallic compounds, Ruthenium.

Affiliation:

Organic Chemistry Laboratory, University of Bayreuth, Universitaetsstrasse 30, D-95440 Bayreuth, Germany.



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