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The Chemistry of Galanthamine. Classical Synthetic Methods and Comprehensive Study on its Analogues

[ Vol. 16 , Issue. 18 ]

Author(s):

Péter Keglevich, Csaba Szántay and László Hazai   Pages 1450 - 1461 ( 12 )

Abstract:


Galanthamine as an Amaryllidaceae alkaloid has an important role in the treatment of Alzheimer’s disease. Some efforts were made to elaborate the total synthesis, and hundreds of its derivatives were prepared to find a more effective molecule with advantageous properties. Moreover, almost every part of the tetracycle was changed; in members of the rings, in the nature and position of the heteroatoms, and ring-opened analogues were also synthesized. In this review the basic synthetic works and the most important derivatives and analogues are overviewed.

Keywords:

Acetylcholinesterase inhibition, Alzheimer's disease, butyrylcholinesterase inhibitor, galanthamine, hexahydrobenzofurobenzazepine, structural analogues.

Affiliation:

Department of Organic Chemistry and Technology, University of Technology and Economics, Budapest, Hungary, H-1111 Budapest, Gellért tér 4. Hungary.



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