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Experimental Models for Evaluation of Nanoparticles in Cancer Therapy

[ Vol. 17 , Issue. 18 ]

Author(s):

Prashant Kesharwani*, Raksha Ghanghoria and Narendra K. Jain   Pages 1725 - 1745 ( 21 )

Abstract:


Nanoparticles (NPs), the submicron-sized colloidal particles, have recently generated enormous interest among biomedical scientists, particularly in cancer therapy. A number of models are being used for exploring NPs safety and efficacy. Recently, cancer cell lines have explored as prominent experimental models for evaluating pharmacokinetic parameters, cell viability, cytotoxicity and drug efficacy in tumor cells. This review aims at thorough compilation of various cancer cell lines and in vivo models for evaluation of efficacy of NPs on one platform. This will provide a basis to explore and improvise pre-clinical models as a prelude to successful cancer research.

Keywords:

Cancer, cell lines studies, chemotherapy, cytotoxicity, ex vivo studies, nanoparticles.

Affiliation:

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI (48201), Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar 470003, MP, Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar 470003, MP

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