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Recent Advances in the Development of Small-Molecular Inhibitors Target HIV Integrase-LEDGF/p75 Interaction

[ Vol. 15 , Issue. 14 ]

Author(s):

Yu Zhao and Zaigang Luo   Pages 1195 - 1208 ( 14 )

Abstract:


Lens epithelium-derived growth factor (LEDGF/p75) plays an essential role in the HIV-1 replication. It acts by tethering integrase (IN) into the host cellular chromatin. Due to its significance of the IN-LEDGF/p75 interaction affords a novel therapeutic approach for the design of new classes of antiretroviral agents. To date, many small molecules have been found to be the inhibitors of INLEDGF/ p75 interaction. This review summarizes recent advances in the development of potential structure-based IN-LEDGF/p75 interaction inhibitors. The work will be helpful to shed light on the antiretroviral drug development pipeline in the next future.

Keywords:

HIV-1; integrase; LEDGF/p75; integrase-LEDGF/p75 interaction inhibitors .

Affiliation:

College of Chemical Engineering, AnHui University of Science & Technology, Huainan 232001, P. R. China.



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