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The Processing of Chitosan and Its Derivatives and Their Application for Postoperative Anti-Adhesion

[ Vol. 15 , Issue. 4 ]


Lin Zhu, Lin Peng and Yu-Qing Zhang   Pages 330 - 337 ( 8 )


The formation of peritoneal adhesions represents one of the most common complications after abdominal surgery, and it increases the difficulty of re-operation. Thus, preventing postoperative adhesions is a major problem in the field of surgical medicine. Due to a lack of good predictive animal models and the complexity of adhesion pathogenesis, attempts to prevent or reduce peritoneal adhesions have been largely unsuccessful. As a result, the study of anti-adhesion drugs and materials has become a hot topic for experts and scholars. The processing and development of chitosan and its derivatives as new anti-adhesion materials is highly valued because chitosan is inexpensive, highly biocompatible, and not cytotoxic, making it a promising anti-adhesion material. Here, we review the sources and preparation of chitosan and the progress made toward producing different types of chitosan and its derivatives for preventing adhesion.


Chitosan, carboxymethyl chitosan, postoperative peritoneal anti-adhesion.


Silk Biotechnology Laboratory, School of Basic Medical and Biological Sciences, Soochow University; No. 199, 702-2303 Room, Renai Road, Dushuhu Higher Edu. Town, Suzhou 215123, P.R China.

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