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The Processing of Chitosan and Its Derivatives and Their Application for Postoperative Anti-Adhesion

[ Vol. 15 , Issue. 4 ]

Author(s):

Lin Zhu, Lin Peng and Yu-Qing Zhang   Pages 330 - 337 ( 8 )

Abstract:


The formation of peritoneal adhesions represents one of the most common complications after abdominal surgery, and it increases the difficulty of re-operation. Thus, preventing postoperative adhesions is a major problem in the field of surgical medicine. Due to a lack of good predictive animal models and the complexity of adhesion pathogenesis, attempts to prevent or reduce peritoneal adhesions have been largely unsuccessful. As a result, the study of anti-adhesion drugs and materials has become a hot topic for experts and scholars. The processing and development of chitosan and its derivatives as new anti-adhesion materials is highly valued because chitosan is inexpensive, highly biocompatible, and not cytotoxic, making it a promising anti-adhesion material. Here, we review the sources and preparation of chitosan and the progress made toward producing different types of chitosan and its derivatives for preventing adhesion.

Keywords:

Chitosan, carboxymethyl chitosan, postoperative peritoneal anti-adhesion.

Affiliation:

Silk Biotechnology Laboratory, School of Basic Medical and Biological Sciences, Soochow University; No. 199, 702-2303 Room, Renai Road, Dushuhu Higher Edu. Town, Suzhou 215123, P.R China.



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