Marton David Gyurko, Attila Stetak, Csaba Soti and Peter Csermely Pages 696 - 704 ( 9 )
The Ras/mitogen activated protein kinase (MAPK) pathway has key importance in development, cell differentiation and senescence, tumorigenesis, learning and memory. The clinical manifestations associated with this highly conserved pathway are called RASopathies. Phenotypic features are diverse and overlapping, but cognitive impairment is a common symptom. Here, we propose an approach based on molecular networks that link learning, memory and forgetting to the RASopathies and various neurodegenerative and neurodevelopmental diseases such as Alzheimer's disease, Parkinson's disease and autism spectrum disorders. We demonstrate the cross-talks of the molecular pathways in RASopathies and memory and the role of compartmentalization in these processes. The approved drugs are also overviewed, and C. elegans is proposed as a viable model system for experimental exploration and compound target prediction.n
Learning, memory, molecular networks, neurodegenerative disorders, Ras/MAPK, RASopathies.
Semmelweis University, Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Budapest, Ulloi ut 26, 1085 Hungary.