Andrea Milelli, Carmela Fimognari, Nicole Ticchi, Paolo Neviani, Anna Minarini and Vincenzo Tumiatti Pages 963 - 977 ( 15 )
Sulforaphane is a natural product that is constantly under biological investigation for its unique biological properties. This naturally occurring isothiocyanate (ITC) and its analogs are the main components of cruciferous vegetables, such as cauliflower, watercress, broccoli, cabbage, Brussels sprouts, widely used as chemopreventive agents. Due to their interesting biological profiles, natural ITCs have been exploited as starting point to develop new synthetic analogs. The present mini-review briefly highlights the most important biological actions of selected new synthetic ITCs focusing on their structure-activity relationships and related synthetic strategies.
Chemopreventive, isothiocyanate, natural products, sulforaphane, structure-activity relationships.
Department for Life Quality Studies Corso d'Augusto, 237, Rimini Campus, 47921 Rimini, Italy.