Submit Manuscript  

Article Details


An Overview on the Development of New Potentially Active Camptothecin Analogs Against Cancer

[ Vol. 14 , Issue. 12 ]

Author(s):

Eliza de Lucas Chazin, Raisa da Rocha Reis, Walcimar Trindade Vellasco Junior, Lucas Fajardo Elmor Moor and Thatyana Rocha Alves Vasconcelos   Pages 953 - 962 ( 10 )

Abstract:


Camptothecin (CPT) and its derivatives comprise an important group of heterocyclic compounds that are well recognized for their anticancer activities. Efforts have been made over the years aiming to develop new CPT analogs with better clinical efficacy, improved pharmacokinetic profile and lower toxicity. First generation of analogs, irinotecan (CPT-11) and topotecan (TPT) was approved for use by FDA in 1996 for the treatment of colorectal (CPT-11) and cervical, ovarian and small lung cancers (TPT). Other analogs of CPT are currently in different phases of clinical trials. As CPT represents an important lead compound in the field of antitumor- research, in this review we will highlight some recent discoveries (2008-2013) on the development of novel camptothecin-based compounds as potential anticancer agents.

Keywords:

Camptothecin, cancer, drugs, homocamptothecin, irinotecan, topoisomerase inhibitors, topotecan.

Affiliation:

Universidade Federal Fluminense, Instituto de Quimica, Programa de Pos-Graduacao em Quimica, Outeiro de Sao Joao Batista, s/nÂș, Centro, Niteroi, 24020-141, Rio de Janeiro, Brazil.



Read Full-Text article