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Naturally Occurring Methyl Salicylate Glycosides

[ Vol. 14 , Issue. 1 ]


Ping Mao, Zizhen Liu, Meng Xie, Rui Jiang, Weirui Liu, Xiaohong Wang, Shen Meng and Gaimei She   Pages 56 - 63 ( 8 )


As an important part of non steroids anti-inflammation drug (NSAIDs), salicylate has developed from natural substance salicylic acid to natrium salicylicum, to aspirin. Now, methyl salicylate glycoside, a new derivative of salicylic acid, is modified with a -COOH group integrated one methyl radical into formic ether, and a -OH linked with a monosaccharide, a disaccharide or a trisaccharide unit by glycosidic linkage. It has the similar pharmacological activities, anti-inflammatory, analgesic, antipyretic and antithrombotic as the previous salicylates’ without resulting in serious side effects, particularly the gastrointestinal toxicity. Owing to the superiority of those significant bioactivities, methyl salicylate glycosides have became a hot research area in NSAIDs for several years. This paper compiles all 9 naturally occurring methyl salicylate glycosides, their distribution of the resource and pharmacological mechanism, which could contribute to the new drug discovery.


Analgesic, anti-inflammation, antipyretic, methyl salicylate glycoside, NSAIDs.


School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China.

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