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Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides

[ Vol. 13 , Issue. 14 ]

Author(s):

Kamil Kuca, Daniel Jun, Kamil Musilek, Miroslav Pohanka, Jana Zdarova Karasova and Ondrej Soukup   Pages 2102 - 2115 ( 14 )

Abstract:


Treatment of intoxications caused by nerve agents and organophosphorus pesticides consists of different approaches. The first approach is called prophylaxis or pre-exposure administration of antidotes such as cholinesterase reactivators or bioscavengers. The second, post-exposure treatment consists of anticholinergic drugs, acetylcholinesterase reactivators and anticonvulsants. This article is aimed at both mentioned approaches, especially focused on cholinesterase reactivators, which are a broad group of structurally different compounds that can be used in prophylaxis (separately or in combination with butyrylcholinesterase) and also as post-exposure treatment.

Keywords:

Acetylcholinesterase, butyrylcholinesterase, nerve agents, pesticides, poisoning, prophylaxis, treatment, antidote, organophosphate, reactivator, protection, oxime, toxicity.

Affiliation:

Center of Advanced Studies, Faculty of Military Health Sciences, Trebesska 1575, 50001 Hradec Kralove, Czech Republic.



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