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Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides

[ Vol. 13 , Issue. 14 ]


Kamil Kuca, Daniel Jun, Kamil Musilek, Miroslav Pohanka, Jana Zdarova Karasova and Ondrej Soukup   Pages 2102 - 2115 ( 14 )


Treatment of intoxications caused by nerve agents and organophosphorus pesticides consists of different approaches. The first approach is called prophylaxis or pre-exposure administration of antidotes such as cholinesterase reactivators or bioscavengers. The second, post-exposure treatment consists of anticholinergic drugs, acetylcholinesterase reactivators and anticonvulsants. This article is aimed at both mentioned approaches, especially focused on cholinesterase reactivators, which are a broad group of structurally different compounds that can be used in prophylaxis (separately or in combination with butyrylcholinesterase) and also as post-exposure treatment.


Acetylcholinesterase, butyrylcholinesterase, nerve agents, pesticides, poisoning, prophylaxis, treatment, antidote, organophosphate, reactivator, protection, oxime, toxicity.


Center of Advanced Studies, Faculty of Military Health Sciences, Trebesska 1575, 50001 Hradec Kralove, Czech Republic.

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