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A Decade of Plasmodium falciparum Metabolic Pathways of Therapeutic Interest to Develop New Selective Antimalarial Drugs

[ Vol. 13 , Issue. 9 ]

Author(s):

Anita Cohen, Aurélien Dumètre and Nadine Azas   Pages 1340 - 1347 ( 8 )

Abstract:


Plasmodium falciparum has a specific metabolism of particular interest because several of its features, with respect to the host human ones, are potential pharmacological targets. Such features have been more intensely investigated since 2002, thanks to the full sequencing of the genome of P. falciparum. In this review, we are interested in the potential metabolic targets of therapeutic interest identified and investigated over the past decade in terms of lead-to-drug development.

Keywords:

Metabolic pathways, metabolic targets of therapeutic interest, plasmodial metabolic features, P. falciparum; plasmodial cellular compartments, selective antimalarial compounds.

Affiliation:

Aix-Marseille Université, MD, Infections Parasitaires, Transmission, Pharmacologie et Thérapeutique IP-TPT UMR MD3, Faculté de Pharmacie: 27 Boulevard Jean Moulin- CS30064-13385 Marseille cedex 05, France.



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