Cristina Maccallini, Marialuigia Fantacuzzi and Rosa Amoroso Pages 1305 - 1310 ( 6 )
In the research of new bioactive compounds able to regulate the L-arginine metabolism, several substituted amidines were disclosed as potent and selective inhibitors of mainly three enzyme families: the nitric oxide synthase, the dimethylarginine dimethylaminohydrolase and the peptidylarginine deiminase. The present work is focused on the last five years developments in the research for amidine-based inhibitors of the mentioned enzymes and on their potential usefulness in neurodegenerative, inflammatory and autoimmune disorders.
Nitric oxide synthase (NOS), dimethylarginine dimethylaminohydrolase (DDAH), peptidylarginine deiminase (PAD), amidines.
Dipartimento di Farmacia, Università di Chieti, via dei Vestini, 66100 Chieti, Italy.